I’m sure Spidey will think of something to stop this wild scheme, whatever it may be.
Amazing Spider-Man (Vol. 1) #2
Published: c. March, 1963?
Cover Date: May, 1963
“Duel to the Death with the Vulture!”
Writer: Stan Lee
Artist: Steve Ditko
Inker: Steve Ditko
Letterer: John Duffy
Vulture was breaking the fourth wall long before She-Hulk and Deadpool.