I feel like Spidey could easily escape Princess Python’s grasp while doing minimal or no harm to her, but what do I know?
Amazing Spider-Man (Vol. 1) #22
Published: c. January, 1965?
Cover Date: March, 1965
“Preeeeeesenting… The Clown, and His Masters of Menace!”
Writer: Stan Lee
Artist: Steve Ditko
Inker: Steve Ditko
Letterer: Artie Simek